Human Sera
Cayman Chemical N6-MethyladenIn 100mg
An inhibitor of PLAP (IC50 3.7 M) that demonstrates high selectivity against the related alkaline phosphatases TNAP and IAP (IC50s 100 M)
Cayman Chemical SureLIghtPE-695 100mg
An allosteric reversible inhibitor of PAR1 on platelets preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 UM also blocks platelet activation induced by thrombin but not by PMA U-46619 or collagen
Cayman Chemical MPPodde 100mg
An S1P1 agonist selectively induces GTPYS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s 4 and 1.5 nM respectively) over those expressing human or rat S1P3 (EC50s 20 and 7.4 UM respectively) transiently reduces blood lymphocyte levels in rats with the levels returning to baseline within 24-48 hours at 0.1 and 1 mg/kg reduces hind paw volume in a rat model of adjuvant-induced arthritis (ID50 0.44 mg/kg) decreases severity in a mouse model of EAE at 0.3 and 1 mg/kg
Cayman Chemical DorIpenmhydrate 50mg
A natural phytochemical with anti-inflammatory effects inhibits the growth of leukemia cells (IC50 1.5 g/ml) inducing apoptosis at 15 M suppresses STAT3-regulated gene expression and prevents angiogenesis
Cayman Chemical -TaxIfolIn 100mg
Differs from 5-fluoro PB-22 by having the fluorine atom at the 3 position rather than the terminal 5 position of the alkyl group intended for forensic and research purposes
Cayman Chemical Latnoprost 50mg
A cationic rhodacyanine dye that inhibits the Hsp70 family of chaperones demonstrates antiproliferative activity against cancer cell lines (EC50s 1.4-2.2 UM in vitro) through its ability to abrogate the interaction of the chaperone with the tumor suppressor p53
Cayman Chemical -Evodamn 50mg
An S1P1 agonist selectively induces GTPYS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s 4 and 1.5 nM respectively) over those expressing human or rat S1P3 (EC50s 20 and 7.4 UM respectively) transiently reduces blood lymphocyte levels in rats with the levels returning to baseline within 24-48 hours at 0.1 and 1 mg/kg reduces hind paw volume in a rat model of adjuvant-induced arthritis (ID50 0.44 mg/kg) decreases severity in a mouse model of EAE at 0.3 and 1 mg/kg
Cayman Chemical 3 4 7-TrIhydroxyIsoflavon 50mg
A selective orally-available antagonist of the 5-HT6 receptor (pKi 9 02-8 92) produces a significant increase in extracellular levels of glutamate and aspartate within the frontal cortex used to evaluate the role of 5-HT6 in learning and memory
Cayman Chemical GardIquImod 50mg
A selective cell permeable inhibitor of the IKB kinases IKKa and IKKB (IC50s 4 and 0 3 UM) inhibits signaling through NF-KB both in cells and in vivo showing excellent pharmacokinetics in mice
Cayman Chemical CInobufagIn 50mg
An activator of Kv7/KCNQ induces relaxation of preconstricted pulmonary arteries isolated from wild type and SERT mice decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT mouse models of pulmonary arterial hypertension at 30 mg/kg per day increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine indirectly antagonizes NMDA receptors via its effects on potassium channels
Cayman Chemical CepharnthIn 50mg
A potent JAK2 inhibitor (Ki 0 45 nM in vitro) that decrease STAT3/5 phosphorylation and inhibits cell proliferation (GI50 33 nM) in a JAK2 V617F mutated cell line induces apoptosis in human T cell lymophotropic virus type 1-infected (IC50 1 UM) downregulating phosphorylated forms of JAK2 and Bcl-2 family proteins
Cayman Chemical SecnIdazole 100mg
A central component of energy storage metabolism and signal transduction in vivo a precursor for ATP and agonist of purinergic receptors
Cayman Chemical TropIsetronhydrochlorIde 100mg
An NRTI reduces HIV-1 p24 antigen levels in the culture supernatant of human peripheral blood lymphocytes infected with laboratory-adapted HIV-1 strains (IC50s 0 0025-0 09 UM) inhibits syncytium formation between various CD4 cell lines and several strains of HIV-1 or HIV-2 (IC50s 0 014-0 61 UM) reduces serum viral titers in a woodchuck model of chronic HBV infection at 40 or 200 mg/kg
Cayman Chemical Metergoln 50mg
A sodium channel blocker and local anesthetic inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner increases the firing threshold in rat sympathetic ganglia at 200 nM blocks cardiac sodium channels in a use-dependent manner at 10 UM inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s 0 78 and 0 37 mM respectively) reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0 6 ml of a 0 5 solution is administered into the perinerve space